Non-Viral Targeted Nucleic Acid Delivery: Apply Sequences for Optimization

Endosomal Escape Pathways for Non-Viral Nucleic Acid Delivery Systems

Nucleic and Amino Acid Sequences Support Structure-Based Viral Classification

Viral capsids ensure viral genome integrity by protecting the enclosed nucleic acids. Interactions between the genome and capsid and between individual capsid proteins (i.e., capsid architecture) are intimate and are expected to be characterized by strong evolutionary conservation. For this reason, a capsid structure-based viral classification has been proposed as a way to bring order to the vi...

Targeted, non-viral gene delivery for cancer gene therapy.

The ability to mediate targeted and specific delivery of therapeutics to cancer cells remains one of the most important hurdles in effectively treating cancer. This aspect also remains as one of the greatest limitations of gene therapy as well. Targeted vectors based on the use of DNA-binding agents attached to cell specific ligands or "molecular conjugates" were created with the goal of over-c...

Recent progress in non-viral nucleic acids delivery.

A major goal of nucleic acid based therapies is to treat inherted and acquired disorders by adding, correcting, suppressing or eplacing genes (Abbas et al., 2008). Advantages of non-viral vectors or delivering nucleic acid based therapies include ease of scale-up, torage stability and improved quality control. The most promisng non-viral vectors have been liposomes and cationic polymers hich co...

Non-Viral Nucleic Acid Delivery Strategies to the Central Nervous System

With an increased prevalence and understanding of central nervous system (CNS) injuries and neurological disorders, nucleic acid therapies are gaining promise as a way to regenerate lost neurons or halt disease progression. While more viral vectors have been used clinically as tools for gene delivery, non-viral vectors are gaining interest due to lower safety concerns and the ability to deliver...